Impact of inflammatory markers on the relationship between sleep quality and incident cardiovascular events in type 2 diabetes

Aims: To analyze relevance of sleep quality with CVD in T2D patients and determine whether inflammation prompted by poor sleep has impact on the CVD. Methods: 332 T2D patients were recruited and their sleep qualities were evaluated by PSQI. The patients with PSQI score >7 were in the poor sleep group, and the others were in the good sleep group. Plasma samples of the patients were obtained to measure inflammatory markers. Correlation analyses and regression analyses were performed to examine the cross-sectional relationships among the poor sleep, inflammatory markers and CVD. Results: The morbidity of CVD was significantly higher in the poor sleep patients compared to the good sleep patients (P = 0.000). PSQI score ORs were both >1 for CVD in model 1 and model 2 (P < 0.05). PSQI score were positively related to IL-6 and ICAM-1(P < 0.05), negatively to FBI (P < 0.05), but not related to CRP in linear regression models. Multiple logistic regression analysis showed IL-6 and ICAM-1, but not FBI and CRP, were related to CVD (P < 0.05). Conclusions: Poor sleep is regarded as a plausible risk factor for CVD in T2D patients, and may be mediated by certain inflammatory markers. (C) 2015 Elsevier Inc. All rights reserved.