DNA vaccine against friend erythroleukaemia virus

被引：0
|
作者：
Síma, P [1 ]
Smahel, M [1 ]
Jelínek, F [1 ]
Vonka, V [1 ]
机构：
[1] Inst Hematol & Blood Transfus, Dept Expt Virol, Prague 12820 2, Czech Republic
来源：
FOLIA BIOLOGICA | 2002年 / 48卷 / 02期
关键词：
DNA vaccine; Friend leukaemia virus;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Plasmids carrying DNA copies of the gag and env genes of FV, which causes erythroleukaemia in susceptible mouse strains, were prepared. Expression of the cloned genes was confirmed by indirect immuno-fluoroscence in cells transfected in vitro. Immunization experiments were performed in DBA/2 mice. Animals were injected with three doses of plasmid either intramuscularly (100 mug DNA per dose) or intradermally (1 mug DNA per dose); in the latter case, a gene gun was used. The FV type A or P was used as a challenge. The immunization with gag- and env-derived vaccines resulted in protective immunity in a high proportion of mice.
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页码：43 / 50
页数：8
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