Keeping out of the kinase domain: Structure-activity relationship (SAR) studies of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione, a potent extracellular signal-related kinase-2 (ERK2) docking domain inhibitor

被引：0

作者：

Jung, Kwan-Young ^{[1
]}

Nevels, Kerrick ^{[1
]}

Worlikar, Shilpa ^{[1
]}

Chauhan, Jamal ^{[1
]}

Smith, Sarice ^{[1
]}

Yap, Jeremy L. ^{[1
]}

Shukla, Sagar ^{[1
]}

Slattery, Joseph ^{[1
]}

Ensey, Mary ^{[1
]}

MacKerell, Alexander D. ^{[1
]}

Shapiro, Paul ^{[1
]}

Fletcher, Steven ^{[1
]}

机构：

[1] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 243卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

314-MEDI

引用

页数：1

共 4 条

[1] Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling
Jung, Kwan-Young
Samadani, Ramin
Chauhan, Jay
Nevels, Kerrick
Yap, Jeremy L.
Zhang, Jun
Worlikar, Shilpa
Lanning, Maryanna E.
Chen, Lijia
Ensey, Mary
Shukla, Sagar
Salmo, Rosene
Heinzl, Geoffrey
Gordon, Caryn
Dukes, Troy
MacKerell, Alexander D., Jr.
Shapiro, Paul
Fletcher, Steven
ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11 (22) : 3706 - 3732
[2] Structure-activity relationship (SAR) studies of 3-(2-amino-ethyl)-5-(4-ethoxy-benzylidene)-thiazolidine-2,4-dione: Development of potential substrate-specific ERK1/2 inhibitors
Li, Qianbin
Al-Ayoubi, Adnan
Guo, Tailiang
Zheng, Hui
Sarkar, Aurijit
Nguyen, Tri
Eblen, Scott T.
Grant, Steven
Kellogg, Glen E.
Zhang, Shijun
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (21) : 6042 - 6046
[3] Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways
Li, Qianbin
Wu, Jingde
Zheng, Hui
Liu, Kai
Guo, Tai L.
Liu, Yuying
Eblen, Scott T.
Grant, Steven
Zhang, Shijun
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (15) : 4526 - 4530
[4] Biological Characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a Selective Sphingosine Kinase-2 Inhibitor and Anticancer Agent
Liu, Kai
Guo, Tai L.
Hait, Nitai C.
Allegood, Jeremy
Parikh, Hardik I.
Xu, Wenfang
Kellogg, Glen E.
Grant, Steven
Spiegel, Sarah
Zhang, Shijun
PLOS ONE, 2013, 8 (02):

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