Analysis of 25 C NBOMe in Seized Blotters by HPTLC and GC-MS

被引:11
|
作者
Duffau, Boris [1 ]
Camargo, Cristian [2 ]
Kogan, Marcelo [2 ]
Fuentes, Edwar [2 ]
Cassels, Bruce Kennedy [3 ]
机构
[1] Publ Hlth Inst Chile, Drug Anal Sect, Santiago, Chile
[2] Univ Chile, Fac Chem & Pharmaceut Sci, Santiago, Chile
[3] Univ Chile, Dept Chem, Fac Sci, Santiago, Chile
关键词
VALIDATION; UNCERTAINTY; GUIDE;
D O I
10.1093/chromsci/bmw095
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated with the potent hallucinogen known as lysergic acid diethylamide (LSD); however, since 2013 blotter stamps with N-2 methoxybenzyl-substituted phenylethylamine hallucinogen designated as "NBOMes" have been seized in Chile. To address this issue with readily accessible laboratory equipment, we have developed and validated a new HPTLC method for the identification and quantitation of 25-C-NBOMe in seized blotters and its confirmation by GC-MS. The proposed method was validated according to SWGTOX recommendations and is suitable for routine analysis of seized blotters containing 25-C-NBOMe. With the validated method, we analyzed 15 real samples, in all cases finding 25-C-NBOMe in a wide dosage range (701.0-1943.5 mu g per blotter). In this situation, we can assume that NBOMes are replacing LSD as the main hallucinogenic drug consumed in blotters in Chile.
引用
收藏
页码:1153 / 1158
页数:6
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