Skin and soft tissue infections among HIV-infected persons in the late combination antiretroviral therapy era

被引：8
|
作者：
Crum-Cianflone, N. F. [1 ,2 ,3 ]
Grandits, G. [4 ]
Weintrob, A. [5 ]
Ganesan, A. [5 ]
Agan, B. [1 ]
Landrum, M. [6 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA
[2] USN, Infect Dis Clin, San Diego Med Ctr, San Diego, CA 92152 USA
[3] USN, Hlth Res Ctr, San Diego, CA 92152 USA
[4] Univ Minnesota, Div Biostat, Minneapolis, MN USA
[5] Walter Reed Natl Mil Med Ctr, Infect Dis Clin, Bethesda, MD USA
[6] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA
来源：
INTERNATIONAL JOURNAL OF STD & AIDS | 2012年 / 23卷 / 07期
基金：
美国国家卫生研究院;
关键词：
HIV; skin and soft tissue infection; SSTI; MRSA; epidemiology; risk factors; RESISTANT STAPHYLOCOCCUS-AUREUS; RISK-FACTORS; MRSA BACTEREMIA; MEN; SEX; COLONIZATION; COHORT;
D O I：
10.1258/ijsa.2011.011360
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Skin and soft tissue infections (SSTIs) occur at higher rates among HIV-infected persons, but current trends and risk factors are largely undefined. We evaluated SSTIs among a prospective cohort of HIV-infected persons during the late combination antiretroviral therapy (cART) era (2006-2010). Of the 1918 HIV-infected persons evaluated, 379 (20%) developed an SSTI during a median of 3.7 years of follow-up; of these, 118 (31%) developed at least one recurrent SSTI. The incidence rate of SSTIs was 101 (95% confidence interval [CI] 93-109) cases per 1000 person-years, and rates did not significantly change during the study period. Compared with not receiving cART and having an HIV RNA level >1000 copies/mL, patients receiving cART with an HIV RNA level <1000 copies/mL had a reduced risk of an SSTI (hazard ratio 0.64, 95% Cl 0.48-0.86, P < 0.01). In summary, initial and recurrent SSTIs are common among HIV-infected persons, and HIV control is associated with a lower risk of SSTIs.
引用
收藏
页码：507 / 511
页数：5
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