Effect of PrP genotype and route of inoculation on the ability of discriminatory Western blot to distinguish scrapie from sheep bovine spongiform encephalopathy

被引：11
|
作者：
Migliore, Sergio [1 ]
Esposito, Elena [1 ]
Pirisinu, Laura [1 ]
Marcon, Stefano [1 ]
Di Bari, Michele [1 ]
D'Agostino, Claudia [1 ]
Chiappini, Barbara [1 ]
Conte, Michela [1 ]
Sezzi, Erminia
De Grossi, Luigi
Agrimi, Umberto [1 ]
Vaccari, Gabriele [1 ]
Nonno, Romolo [1 ]
机构：
[1] Ist Super Sanita, Dept Food Safety & Vet Publ Hlth, I-00161 Rome, Italy
来源：
JOURNAL OF GENERAL VIROLOGY | 2012年 / 93卷
关键词：
EXPERIMENTALLY INFECTED SHEEP; DISEASE-ASSOCIATED PRP; PRION PROTEIN; MOLECULAR ANALYSIS; BSE INFECTIVITY; NATURAL SCRAPIE; SMALL RUMINANTS; TRANSMISSION; MICE; STRAINS;
D O I：
10.1099/vir.0.035469-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Procedures for discriminating scrapie from bovine spongiform encephalopathy (BSE) in sheep are relevant to ascertain whether BSE has entered the sheep population. This study was aimed at investigating whether the suitability of an official EU discriminative method is affected by the sheep PrP genotype and route of infection.
引用
收藏
页码：450 / 455
页数：6
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