A mathematical model for selective differentiation of neural progenitor cells on micropatterned polymer substrates

被引：2
|
作者：
Howk, Cory L. [1 ]
Levine, Howard A. [1 ]
Smiley, Michael W. [1 ]
Mallapragada, Surya K. [2 ]
Nilsen-Hamilton, Marit [3 ]
Oh, Jisun [4 ]
Sakaguchi, Donald S. [4 ]
机构：
[1] Iowa State Univ, Dept Math, Ames, IA 50011 USA
[2] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA
[3] Iowa State Univ, Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA
[4] Iowa State Univ, Dept Genet Dev & Cell Biol, Ames, IA 50011 USA
来源：
MATHEMATICAL BIOSCIENCES | 2012年 / 238卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Receptor kinetics; Interleukin-6 (IL6); Adult hippocampal progenitor cells (AHPC); Cellular differentiation; Extended Fourier amplitude sensitivity test (eFAST); SOLUBLE INTERLEUKIN-6 RECEPTOR; SIGNAL TRANSDUCER GP130; COUPLED REACTION SYSTEMS; SENSITIVITY-ANALYSIS; STEM-CELLS; NEURONAL DIFFERENTIATION; RATE COEFFICIENTS; IL-6; RECEPTOR; SELF-RENEWAL; HALF-LIFE;
D O I：
10.1016/j.mbs.2012.04.001
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The biological hypothesis that the astrocyte-secreted cytokine, interleukin-6 (IL6), stimulates differentiation of adult rat hippocampal progenitor cells (AHPCs) is considered from a mathematical perspective. The proposed mathematical model includes two different mechanisms for stimulation and is based on mass-action kinetics. Both biological mechanisms involve sequential binding, with one pathway solely utilizing surface receptors while the other pathway also involves soluble receptors. Choosing biologically-reasonable values for parameters, simulations of the mathematical model show good agreement with experimental results. A global sensitivity analysis is also conducted to determine both the most influential and non-influential parameters on cellular differentiation, providing additional insights into the biological mechanisms. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：65 / 79
页数：15
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