The Genetic Risk of Kidney Disease in Type 2 Diabetes

被引：33

作者：

Pezzolesi, Marcus G. ^{[1
,2
]}

Krolewski, Andrzej S. ^{[1
,2
]}

机构：

[1] Joslin Diabet Ctr, Sect Genet & Epidemiol, Div Res, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2013年 / 97卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Type; 2; diabetes; Diabetic nephropathy; Kidney disease; Genetic risk; STAGE RENAL-DISEASE; URINARY ALBUMIN EXCRETION; GLOMERULAR-FILTRATION-RATE; GENOME-WIDE SCAN; FAMILIAL PREDISPOSITION; SUSCEPTIBILITY GENES; AFRICAN-AMERICANS; LEUCINE REPEAT; PIMA-INDIANS; LINKAGE SCAN;

D O I：

10.1016/j.mcna.2012.10.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this review, the authors discuss the major approaches being used to identify diabetic nephropathy (DN) susceptibility genes in type 2 diabetes (12D) and highlight the salient findings from studies whereby these approaches have been implemented. The recent advent of next-generation sequencing technology is beginning to impact DN gene mapping strategies. As the field moves forward, family based approaches should greatly facilitate efforts to identify variants in genes that have a major effect on the risk of DN in T2D. To be successful, the ascertainment and comprehensive study of families with multiple affected members is critical.

引用

页码：91 / +

页数：18

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