Chemopreventive Effect of Sarcophine-diol on NOR-1-Induced TPA-Promoted Skin Carcinogenesis in Female HOS:HR-1 Mice

被引：0

作者：

Szymanski, Pawel T. ^{[1
]}

Ahmed, Safwat A. ^{[2
]}

Khalifa, Sherief ^{[3
]}

Tokuda, Harukuni ^{[4
]}

Ichlishi, Eiichiro ^{[5
]}

Iida, Akira ^{[6
]}

Suzuki, Nobutaka ^{[4
]}

Fahmy, Hesham ^{[1
]}

机构：

[1] S Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Brookings, SD 57007 USA

[2] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt

[3] Qatar Univ, Coll Pharm, Doha 02713, Qatar

[4] Kanazawa Univ, Grad Sch Med Sci, Dept Complementary & Alternat Med, Kanazawa, Ishikawa 9208640, Japan

[5] Int Univ Hlth & Welf Hosp, Mibu, Tochigi 3292763, Japan

[6] Kinki Univ, Fac Agr, Nara 6318505, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 02期

关键词：

Sarcophine; Sarcophine-diol; Chemoprevention; Skin cancer; TUMOR-DEVELOPMENT; DERIVATIVES; SARCOTRIOL; CANCER;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cancer chemopreventive potential of sarcophine-diol in a chemical carcinogen initiation promotion experimental tumor model in mice was evaluated. Sarcophine-diol, when given orally, afforded significant protection in the mouse skin cancer model initiated by the topical administration of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) and promoted by 12-O-tetradecanoylphorbol-13-acetate (TPA). These findings, along with our initial reports, suggest that sarcophine-diol is an effective cancer chemopreventive agent, even when administered orally and at a very low dose and thus indicating possible potential human applications in the control of malignancy.

引用

页码：153 / 154

页数：2

共 6 条

[1] Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice
Zhang, Xiaoying
Kundoor, Vipra
Fahmy, Hesham
Dwivedi, Chandradhar
CANCER RESEARCH, 2006, 66 (08)
[2] Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice
Zhang, Xiaoying
Kundoor, Vipra
Khalifa, Sherief
Zeman, David
Fahmy, Hesham
Dwivedi, Chandradhar
CANCER LETTERS, 2007, 253 (01) : 53 - 59
[3] Chemopreventive Effects of Sarcophine-diol on Ultraviolet B-induced Skin Tumor Development in SKH-1 Hairless Mice
Zhang, Xiaoying
Bommareddy, Ajay
Chen, Wei
Hildreth, Michael B.
Kaushik, Radhey S.
Zeman, David
Khalifa, Sherief
Fahmy, Hesham
Dwivedi, Chandradhar
MARINE DRUGS, 2009, 7 (02) : 153 - 165
[4] Dose-Response on the Chemopreventive Effects of Sarcophine-Diol on UVB-Induced Skin Tumor Development in SKH-1 Hairless Mice
Guillermo, Ruth F.
Zhang, Xiaoying
Kaushik, Radhey S.
Zeman, David
Ahmed, Safwat A.
Khalifa, Sherief
Fahmy, Hesham
Dwivedi, Chandradhar
MARINE DRUGS, 2012, 10 (09): : 2111 - 2125
[5] Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot
Kapadia, GJ
Azuine, MA
Sridhar, R
Okuda, Y
Tsuruta, A
Ichiishi, E
Mukainake, T
Takasaki, M
Konoshima, T
Nishino, H
Tokuda, H
PHARMACOLOGICAL RESEARCH, 2003, 47 (02) : 141 - 148
[6] The effect of dietary Vitamin D on UVB induced inflammation and skin carcinogenesis in male and female Skh-1 mice
Tober, Kathleen
Riggenbach, Judy
Harper, Amanda
Clinton, Steven
Fleet, James
Oberyszyn, Tatiana
CANCER RESEARCH, 2009, 69

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