Characterization of an Acid-Inducible Sulfatase in Salmonella enterica Serovar Typhimurium

被引:3
|
作者
Das, Seema [1 ]
Singh, Swati [1 ]
McClelland, Michael [2 ]
Forst, Steven [1 ]
Gyaneshwar, Prasad [1 ]
机构
[1] Univ Wisconsin Milwaukee, Dept Biol Sci, Milwaukee, WI 53202 USA
[2] Univ Calif Irvine, Dept Pathol, Irvine, CA 92717 USA
关键词
KLEBSIELLA-AEROGENES; BACTERIAL SYMBIONT; ARYLSULFATASE; INTESTINE; TYRAMINE; FITNESS; TRACT; GENE; COLI;
D O I
10.1128/AEM.03707-12
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Sulfatases of enteric bacteria can provide access to heavily sulfated mucosal glycans. In this study, we show that aslA (STM0084) of Salmonella enterica serovar Typhimurium LT2 encodes a sulfatase that requires mildly acidic pH for its expression and activity. AslA is not regulated by sulfur compounds or tyramine but requires the EnvZ-OmpR and PhoPQ regulatory systems, which play an important role in pathogenesis.
引用
收藏
页码:2092 / 2095
页数:4
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