Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

被引:123
|
作者
Dalton, Caroline M. [1 ]
Carroll, John [1 ,2 ]
机构
[1] UCL, Dept Cell & Dev Biol, Div Biosci, London WC1E 6BT, England
[2] Monash Univ, Sch Biomed Sci, Dept Anat & Dev Biol, Melbourne, Vic 3800, Australia
关键词
Mitochondria; Oocyte; Asymmetry; MEIOTIC MATURATION; ENDOPLASMIC-RETICULUM; CYTOPLASMIC DYNEIN; ATP; MEIOSIS; REORGANIZATION; CENTROSOME; DNA; PHOSPHORYLATION; REDISTRIBUTION;
D O I
10.1242/jcs.128744
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A fundamental rule of cell division is that daughter cells inherit half the DNA complement and an appropriate proportion of cellular organelles. The highly asymmetric cell divisions of female meiosis present a different challenge because one of the daughters, the polar body, is destined to degenerate, putting at risk essential maternally inherited organelles such as mitochondria. We have therefore investigated mitochondrial inheritance during the meiotic divisions of the mouse oocyte. We find that mitochondria are aggregated around the spindle by a dynein-mediated mechanism during meiosis I, and migrate together with the spindle towards the oocyte cortex. However, at cell division they are not equally segregated and move instead towards the oocyte-directed spindle pole and are excluded from the polar body. We show that this asymmetrical inheritance in favour of the oocyte is not caused by bias in the spindle itself but is dependent on an intact actin cytoskeleton, spindle-cortex proximity, and cell cycle progression. Thus, oocyte-biased inheritance of mitochondria is a variation on rules that normally govern organelle segregation at cell division, and ensures that essential maternally inherited mitochondria are retained to provide ATP for early mammalian development.
引用
收藏
页码:2955 / 2964
页数:10
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