Case Report: Possible autoimmune obsessive-compulsive disorder with postpartum onset

被引：3

作者：

Endres, Dominique ^{[1
]}

Hannibal, Luciana ^{[2
]}

Zaltenbach, Benjamin ^{[1
]}

Schiele, Miriam A. ^{[1
]}

Runge, Kimon ^{[1
]}

Nickel, Kathrin ^{[1
]}

Berger, Benjamin ^{[3
,4
]}

Domschke, Katharina ^{[1
,5
]}

Venhoff, Nils ^{[6
]}

Pruess, Harald ^{[7
,8
]}

van Elst, Ludger Tebartz ^{[1
]}

机构：

[1] Univ Freiburg, Med Ctr, Fac Med, Dept Psychiat & Psychotherapy, Freiburg, Germany

[2] Univ Freiburg, Med Ctr, Fac Med, Dept Gen Pediat Adolescent Med & Neonatol,Lab Cli, Freiburg, Germany

[3] Univ Freiburg, Med Ctr, Fac Med, Clin Neurol, Freiburg, Germany

[4] Helios Clin Pforzheim, Dept Neurol, Pforzheim, Germany

[5] Univ Freiburg, Med Ctr, Fac Med, Ctr Basics Neuromodulat, Freiburg, Germany

[6] Univ Freiburg, Med Ctr, Fac Med, Dept Rheumatol & Clin Immunol,Ctr Basics Neuromod, Freiburg, Germany

[7] Charite Univ Med Berlin, Dept Neurol & Expt Neurol, Berlin, Germany

[8] German Ctr Neurodegenerat Dis DZNE Berlin, Berlin, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

关键词：

autoimmune OCD; cerebrospinal fluid; autoantibody; postpartum; CSF;

D O I：

10.3389/fimmu.2022.970448

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune obsessive-compulsive disorder (OCD) is rare. The case presented here is that of a female patient in her mid-thirties who developed postpartum OCD. Magnetic resonance imaging showed multiple juxtacortical hyperintensities that may have been post-inflammatory in origin. In tissue-based assays using mouse brain slices, the patient's cerebrospinal fluid (CSF) showed novel anti-nucleoli autoantibodies in cerebellar Purkinje cells and cortical neurons. The CSF dopamine and glutamate concentrations were dysregulated. The clinical course and diagnostic findings were compatible with possible autoimmune OCD with postpartum onset.

引用

页数：5

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