Liver function in patients with diabetes mellitus type 2 and hyperlipidemia

Introduction: Liver plays an important role in metabolism of glucose and lipids. There is a mutual relation between liver disease and diabetes, Lipid and glucose metabolism abnormalities may be a consequence of liver disease and reverse, Aim of this research was to analyze the liver function in patients with diabetes mellitus type 2 and hyperlipidemia. Patients and methods: This research has been retrospective-prospective study in which 120 patients have been analyzed divided into 2 groups: 1) patients with diabetes mellitus type 2 and hyperlipidemia (n=60), 2) patients with diabetes mellitus type 2 and with normal lipid status (n=60). In this study only patients who had diabetes mellitus type 2 diagnosed more than two years were included. To analyze liver function we have measured following parameters, bilirubin (total, conjugated and unconjugated), aspartate-amino transferase (AST), alanine-amino transferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), albumin, prothrombin time, HbsAg, antiHbsAg, antiHCV. Data have been analyzed by Student t, Chi square or Fischer's test Results:This study has shown that liver function in patients with diabetes mellitus type 2 and hyperlipidemia was more injured than in those with normal lipid status. Conclusion: Poorly regulated glucose homeostasis and hyperlipidemia may contribute to liver injury. It is necessary to make, from time to time, screening of liver function and lipid profile in patients with diabetes mellitus type 2.