Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

被引：6
|
作者：
Moran, Lisa J. [1 ]
Noakes, Manny [2 ]
Wittert, Gary A. [3 ]
Clifton, Peter M. [4 ]
Norman, Robert J. [1 ]
机构：
[1] Univ Adelaide, Robinson Inst, Adelaide, SA 5006, Australia
[2] CSIRO Food & Nutr Sci, Adelaide, SA 5000, Australia
[3] Univ Adelaide, Royal Adelaide Hosp, Discipline Med, Adelaide, SA 5005, Australia
[4] Univ S Australia, Baker IDI Heart & Diabet Inst, Adelaide, SA 5001, Australia
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 25卷 / 05期
基金：
英国医学研究理事会;
关键词：
cardiovascular disease; inflammation; polycystic ovary syndrome; weight loss; GRADE CHRONIC INFLAMMATION; CARDIOVASCULAR RISK; OBESE WOMEN; MEN;
D O I：
10.1016/j.rbmo.2012.07.013
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular disease risk. The effect of weight loss on the vascular inflammatory markers plasminogen activator inhibitor-1 (PAI-1), asymmetric dimethylarginine (ADMA), soluble vascular cell adhesion molecule-1 (sVCAM-1) and intracellular adhesion molecule-1 (sICAM-1) is unknown. Overweight women with (n = 14) and without (n = 13) PCOS of comparable age and body mass index undertook an 8-week weight-loss programme. Women with PCOS had elevated PAI-1, sVCAM-1 and sICAM-1 before and after weight loss compared with the controls. For all women, sVCAM-1 (P = 0.026) and sICAM-1 (P = 0.04) decreased with weight loss. Women with PCOS have elevated inflammatory markers, which are partially reduced by weight loss. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：500 / 503
页数：4
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