Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer

被引：218
|
作者：
Bauskin, Asne R.
Brown, David A.
Kuffner, Tamara
Johnen, Heiko
Luo, X. Wei
Hunter, Mark
Breit, Samuel N. [1 ]
机构：
[1] St Vincents Hosp, Ctr Immunol, Sydney, NSW 2010, Australia
[2] Univ New S Wales, Sydney, NSW, Australia
来源：
CANCER RESEARCH | 2006年 / 66卷 / 10期
关键词：
D O I：
10.1158/0008-5472.CAN-05-4067
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
引用
收藏
页码：4983 / 4986
页数：4
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