Cytokine-Secreting Activity of Blood Eosinophils in Pulmonary Tuberculosis

被引：2
|
作者：
Kolobovnikova, U. V. [1 ]
Urazova, O. I. [1 ]
Novitsky, V. V. [1 ]
Voronkova, O. V. [1 ]
Naslednikova, I. O. [1 ]
Mikheeva, K. O. [1 ]
Ignatov, M. V. [1 ]
机构：
[1] Siberian State Med Univ, Dept Pathophysiol, Fed Agcy Hlth & Social Dev, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 03期
关键词：
tuberculosis; eosinophils; cytokines; INTERLEUKIN-2; EXPRESSION; GAMMA;
D O I：
10.1007/s10517-012-1705-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Modern immunological studies showed that eosinophilic granulocytes producing the key mediators of cellular and humoral immune response contribute to the common cytokine imbalance developing in tuberculous infection. A significant increase in BCG-induced secretion of IL-2, IL-5, and TNF-alpha by eosinophils in patients with pulmonary tuberculosis indicated high reserve reactivity of eosinophilic cells realizing their functional potential in regulation of the specific resistance reactions of the microorganism under conditions of M. tuberculosis infection.
引用
收藏
页码：319 / 322
页数：4
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