Chemical Modulation of Mitochondria-Endoplasmic Reticulum Contact Sites

被引：24
|
作者：
Magalhaes Rebelo, Ana Paula [1 ]
Dal Bello, Federica [1 ,3 ]
Knedlik, Tomas [1 ]
Kaar, Natasha [1 ]
Volpin, Fabio [1 ]
Shin, Sang Hun [1 ]
Giacomello, Marta [1 ,2 ]
机构：
[1] Univ Padua, Dept Biol, Via U Bassi 58-B, I-35121 Padua, Italy
[2] Univ Padua, Dept Biomed Sci, Via U Bassi 58-B, I-35121 Padua, Italy
[3] Univ Liege, Mol Angiogenesis Lab, GIGA Res, B34,Ave Hop 1, B-4000 Liege, Belgium
来源：
CELLS | 2020年 / 9卷 / 07期
关键词：
mitochondria-endoplasmic reticulum contact sites; mitochondria-associated membranes; pharmacology; drug targets; synthetic and biological compounds; neurodegeneration; diabetes; cancer; ER MEMBRANES; CISPLATIN RESISTANCE; REGULATES APOPTOSIS; MITOFUSIN; AUTOPHAGY; GENE; METABOLISM; PROMOTES; STRESS; CELLS;
D O I：
10.3390/cells9071637
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria-ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies.
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收藏
页数：18
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