Anti-tumor activity of N-thiolated β-lactam antibiotics

被引：38

作者：

Chen, Di ^{[1
]}

Falsetti, Samuel C. ^{[2
,3
]}

Frezza, Michael ^{[1
]}

Milacic, Vesna ^{[1
]}

Kazi, Aslamuzzaman ^{[2
,3
]}

Cui, Qiuzhi Cindy ^{[1
,4
]}

Long, Timothy E. ^{[4
]}

Turos, Edward ^{[4
]}

Dou, Q. Ping ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Pathol, Prevent Program,Barbara Ann Karmanos Canc Inst, Detroit, MI 48201 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Biochem & Mol Biol,Drug Discovery Program, Tampa, FL 33612 USA

[3] Univ S Florida, Drug Discovery Program, H Lee Moffitt Canc Ctr & Res Inst, Dept Interdisciplinary Oncol,Coll Med, Tampa, FL 33612 USA

[4] Univ S Florida, Dept Chem, Ctr Mol Divers Drug Design Discovery & Delivery, Tampa, FL 33620 USA

来源：

CANCER LETTERS | 2008年 / 268卷 / 01期

关键词：

beta-lactam; DNA damage; apoptosis; anti-tumor activity; breast cancer;

D O I：

10.1016/j.canlet.2008.03.047

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An ongoing strategy for cancer treatment is selective induction of apoptosis in cancer over normal cells. N-thiolated beta-lactams were found to induce DNA damage, growth arrest and apoptosis in cultured human cancer cells. However, whether these compounds have a similar effect in vivo has not been studied. We report here that treatment with the P-lactam L-1 caused a significant inhibition of tumor growth in a breast cancer xenograft mouse model, associated with induction of DNA damage and apoptosis in vivo. These results suggest that the synthetic antibiotic N-thiolated beta-lactams hold great potential to be developed as novel anti-cancer drugs. Published by Elsevier Ltd.

引用

页码：63 / 69

页数：7

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