Folate Intake and Risk of Pancreatic Cancer: Pooled Analysis of Prospective Cohort Studies

被引：29

作者：

Bao, Ying ^{[1
,2
]}

Michaud, Dominique S. ^{[3
]}

Spiegelman, Donna ^{[4
,5
]}

Albanes, Demetrius ^{[7
]}

Anderson, Kristin E. ^{[8
,9
]}

Bernstein, Leslie ^{[10
]}

van den Brandt, Piet A. ^{[11
]}

English, Dallas R. ^{[12
]}

Freudenheim, Jo L. ^{[13
]}

Fuchs, Charles S. ^{[14
]}

Giles, Graham G. ^{[12
]}

Giovannucci, Edward ^{[1
,2
,5
,6
]}

Goldbohm, R. Alexandra ^{[15
]}

Hakansson, Niclas ^{[16
]}

Horn-Ross, Pamela L. ^{[17
]}

Jacobs, Eric J. ^{[18
]}

Kitahara, Cari M. ^{[7
]}

Marshall, James R. ^{[19
]}

Miller, Anthony B. ^{[20
]}

Robien, Kim ^{[8
,9
]}

Rohan, Thomas E. ^{[21
]}

Schatzkin, Arthur ^{[7
]}

Stevens, Victoria L. ^{[18
]}

Stolzenberg-Solomon, Rachael Z. ^{[7
]}

Virtamo, Jarmo ^{[22
]}

Wolk, Alicja ^{[16
]}

Ziegler, Regina G. ^{[7
]}

Smith-Warner, Stephanie A. ^{[5
,6
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[7] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[8] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[9] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA

[10] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA 91010 USA

[11] Maastricht Univ, Sch Oncol & Dev Biol, Dept Epidemiol, GROW, Maastricht, Netherlands

[12] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[13] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA

[14] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[15] TNO Qual Life, Dept Prevent & Hlth, Leiden, Netherlands

[16] Karolinska Inst, Div Nutr Epidemiol, Natl Inst Environm Med, Stockholm, Sweden

[17] Canc Prevent Inst Calif, Fremont, CA USA

[18] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[19] Roswell Pk Canc Inst, Dept Canc Prevent & Populat Sci, Buffalo, NY 14263 USA

[20] Univ Toronto, Div Epidemiol, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[21] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[22] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2011年 / 103卷 / 24期

基金：

美国国家卫生研究院;

关键词：

COLORECTAL-CANCER; CALIFORNIA TEACHERS; DIETARY ASSESSMENT; MULTIPLE GENES; FOLIC-ACID; PREVENTION; REPRODUCIBILITY; METAANALYSIS; VALIDATION; PROSTATE;

D O I：

10.1093/jnci/djr431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Epidemiological studies evaluating the association between folate intake and risk of pancreatic cancer have produced inconsistent results. The statistical power to examine this association has been limited in previous studies partly because of small sample size and limited range of folate intake in some studies. Methods We analyzed primary data from 14 prospective cohort studies that included 319 716 men and 542 948 women to assess the association between folate intake and risk of pancreatic cancer. Folate intake was assessed through a validated food-frequency questionnaire at baseline in each study. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random effects model. All statistical tests were two-sided. Results During 7-20 years of follow-up across studies, 2195 pancreatic cancers were identified. No association was observed between folate intake and risk of pancreatic cancer in men and women (highest vs lowest quintile: dietary folate intake, pooled multivariable RR = 1.06, 95% CI = 0.90 to 1.25, P-trend = .47; total folate intake [dietary folate and supplemental folic acid], pooled multivariable RR = 0.96, 95% CI = 0.80 to 1.16, P-trend = .90). No between-study heterogeneity was observed (for dietary folate, P-heterogeneity = .15; for total folate, P-heterogeneity = .22). Conclusion Folate intake was not associated with overall risk of pancreatic cancer in this large pooled analysis.

引用

页码：1840 / 1850

页数：11

共 50 条

[1] Alcohol Intake and Pancreatic Cancer Risk: A Pooled Analysis of Fourteen Cohort Studies
Genkinger, Jeanine M.
Spiegelman, Donna
Anderson, Kristin E.
Bergkvist, Leif
Bernstein, Leslie
van den Brandt, Piet A.
English, Dallas R.
Freudenheim, Jo L.
Fuchs, Charles S.
Giles, Graham G.
Giovannucci, Edward
Hankinson, Susan E.
Horn-Ross, Pamela L.
Leitzmann, Michael
Mannisto, Satu
Marshall, James R.
McCullough, Marjorie L.
Miller, Anthony B.
Reding, Douglas J.
Robien, Kim
Rohan, Thomas E.
Schatzkin, Arthur
Stevens, Victoria L.
Stolzenberg-Solomon, Rachael Z.
Verhage, Bas A. J.
Wolk, Alicja
Ziegler, Regina G.
Smith-Warner, Stephanie A.
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (03) : 765 - 776
[2] Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
Dong-Hyun Kim
Stephanie A. Smith-Warner
Donna Spiegelman
Shiaw-Shyuan Yaun
Graham A. Colditz
Jo L. Freudenheim
Edward Giovannucci
R. Alexandra Goldbohm
Saxon Graham
Lisa Harnack
Eric J. Jacobs
Michael Leitzmann
Satu Mannisto
Anthony B. Miller
John D. Potter
Thomas E. Rohan
Arthur Schatzkin
Frank E. Speizer
Victoria L. Stevens
Rachael Stolzenberg-Solomon
Paul Terry
Paolo Toniolo
Matty P. Weijenberg
Walter C. Willett
Alicja Wolk
Anne Zeleniuch-Jacquotte
David J. Hunter
[J]. Cancer Causes & Control, 2010, 21 : 1919 - 1930
[3] Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
Kim, Dong-Hyun
Smith-Warner, Stephanie A.
Spiegelman, Donna
Yaun, Shiaw-Shyuan
Colditz, Graham A.
Freudenheim, Jo L.
Giovannucci, Edward
Goldbohm, R. Alexandra
Graham, Saxon
Harnack, Lisa
Jacobs, Eric J.
Leitzmann, Michael
Mannisto, Satu
Miller, Anthony B.
Potter, John D.
Rohan, Thomas E.
Schatzkin, Arthur
Speizer, Frank E.
Stevens, Victoria L.
Stolzenberg-Solomon, Rachael
Terry, Paul
Toniolo, Paolo
Weijenberg, Matty P.
Willett, Walter C.
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Hunter, David J.
[J]. CANCER CAUSES & CONTROL, 2010, 21 (11) : 1919 - 1930
[4] Pooled analysis of prospective cohort studies on folate and colorectal cancer.
Kim, DH
Smith-Warner, SA
Hunter, DJ
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2001, 153 (11) : S118 - S118
[5] Intake of Fruits and Vegetables and Risk of Pancreatic Cancer in a Pooled Analysis of 14 Cohort Studies
Koushik, Anita
Spiegelman, Donna
Albanes, Demetrius
Anderson, Kristin E.
Bernstein, Leslie
van den Brandt, Piet A.
Bergkvist, Leif
English, Dallas R.
Freudenheim, Jo L.
Fuchs, Charles S.
Genkinger, Jeanine M.
Giles, Graham G.
Goldbohm, R. Alexandra
Horn-Ross, Pamela L.
Mannisto, Satu
McCullough, Marjorie L.
Millen, Amy E.
Miller, Anthony B.
Robien, Kim
Rohan, Thomas E.
Schatzkin, Arthur
Shikany, James M.
Stolzenberg-Solomon, Rachael Z.
Willett, Walter C.
Wolk, Alicja
Ziegler, Regina G.
Smith-Warner, Stephanie A.
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2012, 176 (05) : 373 - 386
[6] Calcium Intake and Lung Cancer Risk: A Pooled Analysis of 12 Prospective Cohort Studies
Takata, Yumie
Yang, Jae Jeong
Yu, Danxia
Smith-Warner, Stephanie A.
Blot, William J.
White, Emily
Robien, Kimberly
Prizment, Anna
Wu, Kana
Sawada, Norie
Lan, Qing
Park, Yikyung
Gao, Yu-Tang
Cai, Qiuyin
Song, Mingyang
Zhang, Xuehong
Pan, Kathy
Agudo, Antonio
Panico, Salvatore
Liao, Linda M.
Tsugane, Shoichiro
Chlebowski, Rowan T.
Nest, Therese Haugdahl
Schulze, Matthias B.
Johannson, Mattias
Zheng, Wei
Shu, Xiao-Ou
[J]. JOURNAL OF NUTRITION, 2023, 153 (07): : 2051 - 2060
[7] Dietary fiber intake and risk of colorectal cancer - A pooled analysis of prospective cohort studies
Park, Y
Hunter, DJ
Spiegelman, D
Bergkvist, L
Berrino, F
van den Brandt, PA
Buring, JE
Colditz, GA
Freudenheim, JL
Fuchs, CS
Giovannucci, E
Goldbohm, RA
Graham, S
Harnack, L
Hartman, AM
Jacobs, DR
Kato, I
Krogh, V
Leitzmann, MF
McCullough, ML
Miller, AB
Pietinen, P
Rohan, TE
Schatzkin, A
Willett, WC
Wolk, A
Zeleniuch-Jacquotte, A
Zhang, SMM
Smith-Warner, SA
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (22): : 2849 - 2857
[8] Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies
Anita Koushik
Molin Wang
Kristin E. Anderson
Piet van den Brandt
Tess V. Clendenen
A. Heather Eliassen
Jo L. Freudenheim
Jeanine M. Genkinger
Niclas Håkansson
James R. Marshall
Marjorie L. McCullough
Anthony B. Miller
Kim Robien
Thomas E. Rohan
Catherine Schairer
Leo J. Schouten
Shelley S. Tworoger
Ying Wang
Alicja Wolk
Anne Zeleniuch-Jacquotte
Stephanie A. Smith-Warner
[J]. Cancer Causes & Control, 2015, 26 : 1315 - 1327
[9] Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies
Koushik, Anita
Wang, Molin
Anderson, Kristin E.
van den Brandt, Piet
Clendenen, Tess V.
Eliassen, A. Heather
Freudenheim, Jo L.
Genkinger, Jeanine M.
Hakansson, Niclas
Marshall, James R.
McCullough, Marjorie L.
Miller, Anthony B.
Robien, Kim
Rohan, Thomas E.
Schairer, Catherine
Schouten, Leo J.
Tworoger, Shelley S.
Wang, Ying
Wolk, Alicja
Zeleniuch-Jacquotte, Anne
Smith-Warner, Stephanie A.
[J]. CANCER CAUSES & CONTROL, 2015, 26 (09) : 1315 - 1327
[10] Meat and fat intake and pancreatic cancer in a pooled analysis of prospective studies
Mignone, LI
Smith-Warner, SA
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (11) : 2697S - 2697S

← 1 2 3 4 5 →