RNA aptamers targeting cancer stem cell marker CD133

被引：132
|
作者：
Shigdar, Sarah [1 ]
Qiao, Liang [2 ,3 ]
Zhou, Shu-Feng [4 ]
Xiang, Dongxi [1 ]
Wang, Tao [1 ,5 ]
Li, Yong [6 ,7 ]
Lim, Lee Yong [8 ]
Kong, Lingxue [9 ]
Li, Lianhong [10 ]
Duan, Wei [1 ,10 ]
机构：
[1] Deakin Univ, Sch Med, Waurn Ponds, Vic 3217, Australia
[2] Univ Sydney, Storr Liver Unit, Westmead Millennium Inst, Dept Med, Westmead, NSW 2145, Australia
[3] Univ Sydney, Western Clin Sch, Westmead, NSW 2145, Australia
[4] Univ S Florida, Coll Pharm, Dept Pharmaceut Sci, Tampa, FL 33612 USA
[5] Zhengzhou Univ, Coll Nursing, Zhengzhou 450052, Peoples R China
[6] Univ New S Wales, Canc Care Ctr, St George Hosp, Kensington, NSW 2052, Australia
[7] Univ New S Wales, St George Clin Sch, Fac Med, Kensington, NSW 2052, Australia
[8] Univ Western Australia, Lab Drug Delivery, Crawley, WA 6009, Australia
[9] Deakin Univ, Inst Frontier Mat, Waurn Ponds, Vic 3217, Australia
[10] Dalian Med Univ, Dept Pathol & Forens Sci, Dalian 116044, Peoples R China
来源：
CANCER LETTERS | 2013年 / 330卷 / 01期
关键词：
AC133; Cancer stem cell; CD133; RNA aptamer; SELEX; Therapeutic; CD133(+)CD44(+) POPULATION; IDENTIFICATION; EXPRESSION; AC133; THERAPY; PROTEIN; DIFFERENTIATION; IMMUNOTHERAPY; RECOGNITION; PROMININ-1;
D O I：
10.1016/j.canlet.2012.11.032
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The monoclonal antibody against the AC133 epitope of CD133 has been widely used as a cell surface marker of cancer stem cells in several different cancer types. Here, we describe the isolation and characterisation of two RNA aptamers, including the smallest described 15 nucleotide RNA aptamer, which specifically recognise the AC133 epitope and the CD133 protein with high sensitivity. As well, both these aptamers show superior tumour penetration and retention when compared to the AC133 antibody in a 3D tumour sphere model. These novel CD133 aptamers will aid future development of cancer stem cell targeted therapeutics and molecular imaging. Crown Copyright (C) 2012 Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：84 / 95
页数：12
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