Pou2f3/Skn-1a Is Necessary for the Generation or Differentiation of Solitary Chemosensory Cells in the Anterior Nasal Cavity

被引：34

作者：

Ohmoto, Makoto ^{[1
]}

Yamaguchi, Tatsuya ^{[2
]}

Yamashita, Junpei ^{[2
]}

Bachmanov, Alexander A. ^{[1
]}

Hirota, Junji ^{[2
,3
]}

Matsumoto, Ichiro ^{[1
]}

机构：

[1] Monell Chem Senses Ctr, Philadelphia, PA 19104 USA

[2] Tokyo Inst Technol, Grad Sch Biosci & Bioengn, Dept Bioengn, Yokohama, Kanagawa 2268501, Japan

[3] Tokyo Inst Technol, Ctr Biol Resources & Informat, Yokohama, Kanagawa 2268501, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 10期

关键词：

transcription factor; Pou2f3; solitary chemosensory cell; differentiation; taste cell; CHEMORECEPTOR CELLS; TASTE; BITTER;

D O I：

10.1271/bbb.130454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Solitary chemosensory cells in the non-neuronal epithelium of the anterior nasal cavity have bitter taste cell-like molecular characteristics and are involved in the detection of noxious substances. Here, we demonstrate. that Pou2f3/Skn-1a, which is necessary for generation of sweet, umami, and bitter taste cells, is also necessary for the generation or differentiation of solitary chemosensory cells.

引用

页码：2154 / 2156

页数：3

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