Palladium-Catalyzed Cross-Coupling of Aryl Halides Using Organotitanium Nucleophiles

被引：67
|
作者：
Lee, Hang Wai
Lam, Fuk Loi
So, Chau Ming
Lau, Chak Po
Chan, Albert S. C.
Kwong, Fuk Yee [1 ]
机构：
[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Kowloon, Hong Kong, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 40期
关键词：
cross-coupling; palladium; phosphanes; sulfones; titanium; SUZUKI-MIYAURA; SULFONYL CHLORIDES; TOSYLATES; REAGENTS; ARENESULFONATES; LIGANDS; MESYLATES; GRIGNARD;
D O I：
10.1002/anie.200904033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
They make a good couple: Catalysts generated from Pd (OAc)2 and indolylphosphine ligands are highly effective in the titanium-mediated coupling of aryl halides. Catalyst loadings as low as 0.05 mol % Pd can be used. The mild reaction conditions also allow the coupling of aryl sulfonyl chlorides with aryl titanium reagents to generate diaryl sulfones. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：7436 / 7439
页数：4
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