The INK4α/ARF locus in murine tumorigenesis

被引：87
|
作者：
Serrano, M [1 ]
机构：
[1] Ctr Nacl Biotecnol, Dept Immunol & Oncol, E-28049 Madrid, Spain
来源：
CARCINOGENESIS | 2000年 / 21卷 / 05期
关键词：
D O I：
10.1093/carcin/21.5.865
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16(INK4a) and p19(ARF), has provided a great insight on the functioning of the tumor suppressors Ph and p53, respectively. Present evidence indicates that the INK4a/ARF locus is transcriptionally activated by oncogenic stresses, resulting in cell-cycle arrest or apoptosis, Here, I review the evidence accumulated on the involvement of the INK4a/ ARF locus in murine turnorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus.
引用
收藏
页码：865 / 869
页数：5
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