Spectrophotometric Determination of Promethazine Hydrochloride Based on Inhibition of Hemoglobin

被引：0
|
作者：
Chen, Ya Hong [1 ]
Tian, Feng Shou [1 ]
Liu, Hui Fang [1 ]
机构：
[1] Zhoukou Normal Univ, Dept Chem, Zhoukou 466000, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2009年 / 21卷 / 06期
关键词：
Catalytic spectrophotometry; Promethazine hydrochloride; Hemoglobin; HYDROGEN-PEROXIDE; ELECTRODE; OXYGEN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly sensitive and simple catalytic spectrophotometric method for the determination of promethazine hydrochloride based on inhibitory effect of promethazine hydrochloride on the hemoglobin-catalyzed the reaction of H2O2 and acid chrome blue K (ACBK) was developed. The concentration of promethazine hydrochloride is linear with the percentage inhibition (I %) of system under the optimal experimental conditions. The calibration graph is linear in range 6.23 x 10(-8) to 1.56 x 10(-5) mol L-1 with the detection limit of 9.32 x 10(-10) mol L-1. This method can be used for the determination of promethazine hydrochloride in tablets and injection solution of promethazine hydrochloride with satisfactory results.
引用
收藏
页码：4489 / 4494
页数：6
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