Ventilatory and metabolic adaptations to walking and cycling in patients with COPD

To test the hypothesis that in chronic obstructive pulmonary disease (COPD) patients the ventilatory and metabolic requirements during cycling and walking exercise are different, paralleling the level of breathlessness, we studied nine patients with moderate to severe, stable COPD. Each subject underwent two exercise protocols: a 1-min incremental cycle ergometer exercise (C) and a "shuttle" walking test (W). Oxygen uptake ((V) over dot o(2)), CO2 output ((V) over dot CO2), minute ventilation ((V) over dot E), and heart rate (HR) were measured with a portable telemetric system. Venous blood lactates were monitored. Measurements of arterial blood gases and pH were obtained in seven patients. Physiological dead space-tidal volume ratio (V-D/V-T) was computed. At peak exercise, W vs. C (V) over dot O-2, (V) over dot E, and HR values were similar, whereas (V) over dot CO2 (848 +/- 69 vs. 1,225 +/- 45 ml/min; P < 0.001) and lactate (1.5 +/- 0.2 vs. 4.1 +/- 0.2 meq/l; P < 0.001) were lower, Delta(V) over dot E/Delta(V) over dot CO2 (35.7 +/- 1.7 vs. 25.9 +/- 1.3; P < 0.001) and Delta HR/Delta(V) over dot O-2 values (51 +/- 3 vs. 40 +/- 4; P < 0.05) were significantly higher. Analyses of arterial blood gases at peak exercise revealed higher V-D/V-T and lower arterial partial pressure of oxygen values for W compared with C. In COPD, reduced walking capacity is associated with an excessively high ventilatory demand. Decreased pulmonary gas exchange efficiency and arterial hypoxemia are likely to be responsible for the observed findings.