Development and Validation of an LC-ESI-MS/MS Method for Simultaneous Determination of Ligustroflavone and Rhoifolin in Rat Plasma and Its Application to a Pharmacokinetic Study

被引：9
|
作者：
Liu, Hong [1 ]
Xu, Cheng [2 ]
Wang, Wei [3 ]
Zhao, Yue [4 ]
机构：
[1] East Med Dist Linyi Peoples Hosp, Dept Infect Dis, Linyi 276000, Peoples R China
[2] Linyi Peoples Hosp, Dept Infect Dis, Linyi 276000, Peoples R China
[3] China Japan Friendship Hosp, Tradit Chinese Med Dept Digest, Beijing 100029, Peoples R China
[4] Dalian Med Univ, Sch Postgrad, Dalian 116023, Peoples R China
来源：
JOURNAL OF CHROMATOGRAPHIC SCIENCE | 2017年 / 55卷 / 03期
关键词：
PERFORMANCE LIQUID-CHROMATOGRAPHY; FLAVONOIDS; LEAVES; MS;
D O I：
10.1093/chromsci/bmw181
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A selective and sensitive liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was developed for the simultaneous determination of ligustroflavone and rhoifolin in rat plasma. Chromatographic separation was performed on a Venusil HILIC column using an isocratic mobile phase consisting of acetonitrile/water/formic acid (75:25:0.1, v/v/v). The detection was achieved using a triple-quadrupole tandem MS in negative ionization through selected reaction monitoring (SRM) mode. The calibration curves of both analytes in plasma showed good linearity over the concentration ranges of 3-300 ng/mL for ligustroflavone, and 2-200 ng/mL for rhoifolin. This assay was used to investigate the pharmacokinetics of ligustroflavone and rhoifolin in rats.
引用
收藏
页码：267 / 274
页数：8
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