Tremor in Parkinson's disease

被引：34
|
作者：
Carr, J [1 ]
机构：
[1] Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Ctr Neurodegenerat Disorders, Vancouver, BC V5Z 1M9, Canada
来源：
PARKINSONISM & RELATED DISORDERS | 2002年 / 8卷 / 04期
关键词：
Parkinson's disease; tremor; substantia nigra;
D O I：
10.1016/S1353-8020(01)00037-2
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Rest tremor is a common feature of Parkinson's disease, but its underlying pathophysiology remains unknown. This review hypothesizes that tremor is related to selective loss of components of the substantia nigra. The relative scarcity of tremor in related Parkinsonian conditions may indicate a dissociation associated with different pathological involvement of the substantia nigra and its connections. Connections of the subthalamic nucleus with the pallidum, modified by cortical and nigral inputs, allow for the transfer of tremorogenic activity to the thalamus. Thalamo-cortical interactions, tempered by cerebellar input, generate the final common pathway for tremor production. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：223 / 234
页数：12
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