Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals:: Possible expansion of the role of OspE in Lyme disease pathogenesis

被引：55

作者：

Hovis, KM

Tran, E

Sundy, CM

Buckles, E

McDowell, JV

Marconi, RT

机构：

[1] Virginia Commonwealth Univ, Med Coll Virginia, Dept Microbiol & Immunol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Med Coll Virginia, Ctr Study Biol Complex, Richmond, VA 23298 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 03期

关键词：

D O I：

10.1128/IAI.74.3.1967-1972.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.

引用

页码：1967 / 1972

页数：6

共 3 条

[1] The OspE-Related Proteins Inhibit Complement Deposition and Enhance Serum Resistance of Borrelia burgdorferi, the Lyme Disease Spirochete
Kenedy, Melisha R.
Akins, Darrin R.
INFECTION AND IMMUNITY, 2011, 79 (04) : 1451 - 1457
[2] Differential binding of host complement inhibitor factor h by Borrelia burgdorferi erp surface proteins:: a possible mechanism underlying the expansive host range of Lyme disease Spirochetes
Stevenson, B
El-Hage, N
Hines, MA
Miller, JC
Babb, K
INFECTION AND IMMUNITY, 2002, 70 (02) : 491 - 497
[3] Microbially produced factor H binding proteins of pathogenic spirochetes: From lyme disease to periodontal disease: Analysis of expression, structure and diverse functional roles
Hovis, Kelley M.
McDowell, John V.
Saldon, Tania
Gordon, David L.
Stamm, Lola
Marconi, Richard T.
MOLECULAR IMMUNOLOGY, 2007, 44 (1-3) : 186 - 186

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