OXYTOCIN IN THE CARDIOVASCULAR RESPONSES TO STRESS

被引：0
|
作者：
Wsol, A. [1 ]
Cudnoch-Jedrzejewska, A. [1 ]
Szczepanska-Sadowska, E. [1 ]
Kowalewski, S. [1 ]
Puchalska, L. [1 ]
机构：
[1] Med Univ Warsaw, Dept Expt & Clin Physiol, PL-00927 Warsaw, Poland
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2008年 / 59卷
关键词：
stress; oxytocin; oxytocin receptors; brain; neuropeptides;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The present study was designed to determine the role of central oxytocin (OXY) in regulation of the cardiovascular responses to the alarming stress. Three groups of male, normotensive Sprague Dawley rats, received intracerebroventricular (i.c.v.) infusion of one of the following: 1) vehicle, 2) OXY or 3) OXY antagonist (OXANT). Mean arterial blood pressure (MABP) and heart rate (HR) were recorded at rest, during and after application of the alarming stressor (air jet). Under resting conditions the i.c.v. infusions of vehicle, OXY or OXYANT did not influence the cardiovascular parameters. The alarming stressor evoked significant increases in MABP and HR that were significantly greater in the rats receiving i.c.v. infusion of oxytocin antagonist than ill those receiving vehicle or OXY. The study provides evidence that stimulation of the brain oxytocin receptors by endogenous oxytocin plays significant role in inhibition of cardiovascular responses to stress.
引用
收藏
页码：123 / 127
页数：5
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