Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21WAF1/CIP1

被引：37
|
作者：
Kim, MJ
Yoo, YA
Kim, HJ
Kang, S
Kim, YG
Kim, JS
Yoo, YD [1 ]
机构：
[1] Korea Univ, Coll Med, Grad Sch Med, Seoul 136705, South Korea
[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136705, South Korea
[3] Yonsei Univ, Dept Internal Med, Coll Med, Seoul 135270, South Korea
[4] Korea Univ, Coll Med, Div Brain Korea 21 Program Biomed Sci, Seoul 136705, South Korea
[5] Korea Univ, Coll Med, Dept Internal Med, Seoul 136705, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 02期
关键词：
MRPL41; p21(WAF1/CIP1); serum starvation; p53; cell cycle; p27 (Kip1);
D O I：
10.1016/j.bbrc.2005.10.064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27(Kip1) in the absence of p53. This study found that MRPL41 mediates the p21(WAF1/CIP1)-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and P27(Kip1) levels under the growth inhibitory conditions. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：1179 / 1184
页数：6
相关论文
共 50 条
  • [1] Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression
    Stewart Bates
    Kevin M Ryan
    Andrew C Phillips
    Karen H Vousden
    Oncogene, 1998, 17 : 1691 - 1703
  • [2] Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression
    Bates, S
    Ryan, KM
    Phillips, AC
    Vousden, KH
    ONCOGENE, 1998, 17 (13) : 1691 - 1703
  • [3] p21WAF1/Cip1:: more than a break to the cell cycle?
    Dotto, GP
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2000, 1471 (01): : M43 - M56
  • [4] p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation
    E V Broude
    M E Swift
    C Vivo
    B-D Chang
    B M Davis
    S Kalurupalle
    M V Blagosklonny
    I B Roninson
    Oncogene, 2007, 26 : 6954 - 6958
  • [5] p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation
    Broude, E. V.
    Swift, M. E.
    Vivo, C.
    Chang, B-D
    Davis, B. M.
    Kalurupalle, S.
    Blagosklonny, M. V.
    Roninson, I. B.
    ONCOGENE, 2007, 26 (48) : 6954 - 6958
  • [6] Interferon Regulatory Factor 1 (IRF-1) induces p21WAF1/CIP1 dependent cell cycle arrest and p21WAF1/CIP1 independent modulation of survivin in cancer cells
    Armstrong, Michaele J.
    Stang, Michael T.
    Liu, Ye
    Gao, Jinbo
    Ren, Baoguo
    Zuckerbraun, Brian S.
    Mahidhara, Raja S.
    Xing, Quanhua
    Pizzoferrato, Eva
    Yim, John H.
    CANCER LETTERS, 2012, 319 (01) : 56 - 65
  • [7] Involvement of p21Waf1/Cip1 in protein kinase C alpha-induced cell cycle progression
    Besson, A
    Yong, VW
    MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (13) : 4580 - 4590
  • [8] The role of p21Waf1/CIP1 as a Cip/Kip type cell-cycle regulator in oral squamous cell carcinoma (Review).
    Perez-Sayans, Mario
    Suarez-Penaranda, Jose-Manuel
    Gayoso-Diz, Pilar
    Barros-Angueira, Francisco
    Gandara-Rey, Jose-Manuel
    Garcia-Garcia, Abel
    MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, 2013, 18 (02): : E219 - E225
  • [9] Mitochondrial ribosomal protein S36 delays cell cycle progression in association with p53 modification and p21WAF1/CIP1 expression
    Chen, Yeong-Chang
    Chang, Meng-Ya
    Shiau, Ai-Li
    Yo, Yi-Te
    Wu, Chao-Liang
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 100 (04) : 981 - 990
  • [10] An overview of the cell cycle arrest protein, p21WAF1
    Harada, K
    Ogden, GR
    ORAL ONCOLOGY, 2000, 36 (01) : 3 - 7
12345