Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat

被引：14

作者：

Mondo, Charles Kiiza ^{[1
]}

Yang, Wan-Song ^{[1
]}

Su, Ji-Zhou ^{[1
]}

Huang, Ti-Gang ^{[1
]}

机构：

[1] Tianjin Med Univ, Inst Cardiol, Hosp 2, Tianjin 300211, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2006年 / 28卷 / 05期

关键词：

atorvastatin; dexamethasone; blood pressure; rat;

D O I：

10.1080/10641960600798713

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days. Dex increased systolic blood pressure (SBP) from 109 +/- 1.8 to 135 +/- 0.6 mmHg and plasma superoxide (5711 +/- 284.9 saline, 7931 +/- 392.8 U/ml dex, P < 0.001). In this prevention study, SBP in the atorva + dex group was increased from 115 +/- 0.4 to 124 +/- 1.5 mmHg, but this was significantly lower than in the dex-only group (P'< 0.05). Atorva reversed dex-induced hypertension (129 +/- 0.6 mmHg, vs. 135 +/- 0.6 mmHg P'< 0.05) and decreased plasma superoxide (7931 +/- 392.8 dex, 1187 +/- 441.2 atorva + dex, P < 0.0001). Plasma nitrate/nitrite (NOx) was decreased in dex-treated rats compared to saline-treated rats (11.2 +/- 1.08 mu m, 15.3 +/- 1.17 mu m, respectively, P < 0.05). Atorva affected neither plasma NOx nor thymus weight. Thus, atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.

引用

页码：499 / 509

页数：11

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