Anti-Hypertensive Drug Felodipine Exerts Influence on the Metabolism of Serotonin

被引：0

作者：

Huang, Qing ^{[1
]}

Huang, Weijian ^{[2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Cixi Hosp, Cixi 315300, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2018年 / 37卷 / 03期

关键词：

anti-hypertensive drug; felodipine; serotonin; UDP-GLUCURONOSYLTRANSFERASES UGTS; HYPERTENSION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Felodipine, a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b, is clinically employed to treat mild to moderate essential hypertension. This study aims to determine the inhibition of felodipine on the activity of UDP-glucuronosyltransferase (UGT) 1A6 which is the main enzyme catalyzing the metabolic elimination of serotonin. 100 mu M of felodipine was used as the initial screening concentration to determine the inhibition of felodipine on the activity of UGT1A6, and approximately 100% activity of UGT1A6 was inhibited by 100 mu M of felodipine. Taken together, our recent study gave a rapid report demonstrating the inhibition of anti-hypertensive drug felodipine on the metabolism of serotonin.

引用

页码：596 / 598

页数：3

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