EPR INVESTIGATION OF SOME GAMMA-IRRADIATED MEDICINES

被引：0
|
作者：
Aleksieva, Katerina I. [1 ]
Yordanov, Nicola D. [1 ]
机构：
[1] Bulgarian Acad Sci, Inst Catalysis, Acad G Bonchev St,Bl 11, BU-1113 Sofia, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2016年 / 69卷 / 11期
关键词：
medical tablets; gamma-irradiation; EPR; ELECTRON-SPIN-RESONANCE; DRUGS; EXCIPIENTS; RADIATION; DECAY;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The results of EPR studies on three medical tablets - Galantamine, Cytisine and Tribulus terrestris before and after gamma-irradiation are reported. Before irradiation Galantamine and Cytisine tablets are EPR silent, whereas Tribulus terrestris show a broad singlet line with g factor 2.2084 +/- 0.002. The same spectrum is recorded after irradiation. After gamma-sterilization, however, Galantamine and Cytisine tablets exhibit a typical EPR spectrum due to gamma induced free radicals in lactose used as an excipient. These stable free radicals can be used for identification of radiation processing for a long time after it.
引用
收藏
页码：1423 / 1428
页数：6
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