Two coupled enzymes perform in parallel the 'AND' and 'InhibAND' logic gate operations

被引：59

作者：

Baron, R ^{[1
]}

Lioubashevski, O ^{[1
]}

Katz, E ^{[1
]}

Niazov, T ^{[1
]}

Willner, I ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 06期

关键词：

D O I：

10.1039/b518205k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The coupled activation of two enzymes: glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), is used to construct the parallel-operating AND and InhibAND logic gates. The added substrates for the respective enzymes, glucose and H2O2, act as the gate inputs, while the biocatalytically generated NADH and gluconic acid provide the output signals that follow the operations of the gates. The two gates are generated in the same vial, thus allowing the logic operations to take place in parallel, and the simultaneous readout of the functions of the gates.

引用

页码：989 / 991

页数：3

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