Preparation and characterization of vancomycin-loaded chitosan/PVA/PEG hydrogels for wound dressing

被引：30
|
作者：
Naeimi, Mitra [1 ]
Tajedin, Ramtin [1 ]
Farahmandfar, Farmehr [1 ]
Naeimi, Maryam [2 ]
Monajjemi, Majid [3 ]
机构：
[1] Islamic Azad Univ, Cent Tehran Branch, Dept Biomed Engn, Tehran, Iran
[2] Amirkabir Univ Technol, Tehran Polytech, Dept Biomed Engn, Tehran, Iran
[3] Islamic Azad Univ, Cent Tehran Branch, Dept Chem Engn, Tehran, Iran
来源：
MATERIALS RESEARCH EXPRESS | 2020年 / 7卷 / 09期
关键词：
porous; hydrogel; antibacterial; POLY(VINYL ALCOHOL); ANTIBACTERIAL; DELIVERY;
D O I：
10.1088/2053-1591/abb154
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
This study describes a drug-loaded porous hydrogel for delivery of vancomycin. Hydrogels based on chitosan (CS), Polyvinyl alcohol (PVA) and Polyethylene glycol (PEG) were prepared by lyophilization. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and fourier transform infrared (FTIR) spectroscopy were used to characterize the structures. Water uptake percentage and vancomycin release were also measured. The antibacterial activity againstStaphylococcus aureuswas investigated. According to the results, mean pore diameter (MPD) was decreased by addition of PEG and reached to 1.3 0.5 mu m. On the other hand, 43% decrease in water content of the hydrogels showed along with the incorporation of PEG. The inhibition zone confirmed antibacterial effect of the vancomycin-loaded hydrogels. The porous CS/PVA/PEG hydrogels containing vancomycin could be good candidates to potentially be used as wound dressing.
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页数：9
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