A-Chymotrypsin and Urease Inhibitory Activity of Diversolides C, D and E from the Roots of Ferula Diversivittata

被引：0

作者：

Khan, Saleha Suleman ^{[1
]}

Khan, Ajmal ^{[1
]}

Marasini, Bishnu P. ^{[1
]}

Saba, Nikhat ^{[2
]}

Ahmad, Viqar Uddin ^{[1
]}

Iranshahi, Mehrdad ^{[3
]}

Hosseini, Seyyed Tahmineh ^{[3
]}

Choudhary, Muhammad Iqbal ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[2] Jinnah Univ Women, Dept Chem, Karachi 74600, Pakistan

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2012年 / 34卷 / 03期

关键词：

Ferula diversivittata; alpha-chymotrypsin; urease; diversolide; SESQUITERPENE COUMARINS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sesquiterpene Intone derivatives, diversolides-C (giferolide) (1), -D (malafilin) (2), and -E (fegvolide) (3), isolated from the roots of Ferula diversivittata, Regel. & Schmalh, were evaluated for alpha-chymotrypsin and urease inhibition activities. Diversolide-E (3) was found to be a moderate inhibitor against both enzymes while all others were found to be inactive. The IC50 +/- SEM values of 3 were 388.2 +/- 1.7 mu M, and 116.0 +/- 4.8 mu M for alpha-chymotrypsin and urease, respectively.

引用

页码：699 / 701

页数：3

共 36 条

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