High Expression of FoxP1 Is Associated With Improved Survival in Patients With Non-Small Cell Lung Cancer

被引：65
|
作者：
Feng, Jian [1 ]
Zhang, Xuesong [1 ]
Zhu, Huijun [2 ]
Wang, Xudong [3 ]
Ni, Songshi [1 ]
Huang, Jianfei [2 ]
机构：
[1] Nantong Univ, Dept Resp Med, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Univ, Dept Pathol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China
[3] Nantong Univ, Dept Lab Med, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2012年 / 138卷 / 02期
关键词：
FoxP1; Non-small cell lung cancer; Tissue microarray; Immunohistochemistry; Prognosis; FORKHEAD TRANSCRIPTION FACTOR; ANDROGEN RECEPTOR; PROSTATE-CANCER; LYMPHOMA; TARGET; GENE;
D O I：
10.1309/AJCPDHQFNYJZ01YG
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
FoxP1 has been reported to be expressed in several types of human malignant tumors, and has been associated with metastasis and patient prognosis. Quantitative real-time polymerase chain reaction (PCR) and immunohistochemical analysis with tissue microarray were used to characterize the expression of FoxP1 in non-small cell lung cancer (NSCLC). It was revealed that the expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NSCLC tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively). The expression of FoxP1 protein in NSCLC was related to gender, histologic type, and 5-year survival rate (all P < .05). Finally, we evaluated the prognostic significance of the expression of FoxP1 in a group of patients. Kaplan-Meier survival and Cox regression analyses showed that low expression of FoxP1 (P < .001) and later stage grouping by TNM (P = .022) were independent factors predicting poor prognosis for NSCLC.
引用
收藏
页码：230 / 235
页数：6
相关论文
共 50 条
  • [1] High levels of apoptosis are associated with improved survival in non-small cell lung cancer
    Macluskey, M
    Baillie, R
    Chandrachud, LM
    Pendleton, N
    Schor, AM
    ANTICANCER RESEARCH, 2000, 20 (3B) : 2123 - 2128
  • [2] Foxp3 expression in patients with non-small cell lung cancer
    Kalofonos, H.
    Dimitrakopoulos, F. D.
    Papadaki, H.
    Antonacopoulou, A. G.
    Kottorou, A. E.
    Scopa, C. D.
    Gotsis, A.
    Mouzaki, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)
  • [3] Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer
    Srinivasan, Malini
    Parwani, Anil V.
    Hershberger, Pamela A.
    Lenzner, Diana E.
    Weissfeld, Joel L.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 123 (1-2): : 30 - 36
  • [4] High miRNA-221 expression is associated with poor overall survival in patients with non-small cell lung cancer
    Liu, Ya
    Wang, Jing
    BIOMEDICAL RESEARCH-INDIA, 2017, 28 (07): : 2975 - 2980
  • [5] Insulin receptor expression and survival of patients with non-small cell lung cancer
    Kim, Jin-Soo
    Kim, Edward S.
    Liu, Diane
    Lee, Jack
    Solis, Luisa
    Behrens, Carmen
    Lippman, Scott
    Hong, Waun Ki
    Wistuba, Ignacio I.
    Lee, Ho-Young
    CANCER RESEARCH, 2011, 71
  • [6] Cytoplasmic clusterin expression is associated with longer survival in patients with resected non-small cell lung cancer
    Albert, J. M.
    Gonzalez, A.
    Diaz, R.
    Massion, P. P.
    Chen, H.
    Shyr, Y.
    Lambright, E. S.
    Sandler, A.
    Johnson, D. H.
    Lu, B.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (03): : S478 - S479
  • [7] Cytoplasmic clusterin expression is associated with longer survival in patients with resected non-small cell lung cancer
    Albert, Jeffrey M.
    Gonzalez, Adriana
    Massion, Pierre P.
    Chen, Heidi
    Olson, Sandra J.
    Shyr, Yu
    Diaz, Roberto
    Lambright, Eric S.
    Sandler, Alan
    Carbone, David P.
    Putnam, Joe B., Jr.
    Johnson, David H.
    Lu, Bo
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (09) : 1845 - 1851
  • [8] Metagenes Associated with Survival in Non-Small Cell Lung Cancer
    Urgard, Egon
    Vooder, Tonu
    Vosa, Urmo
    Vaelk, Kristjan
    Liu, Mingming
    Luo, Cheng
    Hoti, Fabian
    Roosipuu, Retlav
    Annilo, Tarmo
    Laine, Jukka
    Frenz, Christopher M.
    Zhang, Liqing
    Metspalu, Andres
    CANCER INFORMATICS, 2011, 10 : 175 - 183
  • [9] Association of FOXP3 Expression with Non-small Cell Lung Cancer
    Dimitrakopoulos, Fotinos-Ioannis D.
    Papadaki, Helen
    Antonacopoulou, Anna G.
    Kottorou, Anastasia
    Gotsis, Andreas D.
    Scopa, Chrisoula
    Kalofonos, Haralabos P.
    Mouzaki, Athanasia
    ANTICANCER RESEARCH, 2011, 31 (05) : 1677 - 1683
  • [10] Expression of the EGFR suppressor LRIG1 is associated with survival in non-small cell lung cancer
    Kvarnbrink, Samue
    Edlund, Karolina
    Bolling, Johan
    Micke, Patrick
    Hedman, Hakan
    Johansson, Mikael
    CLINICAL CANCER RESEARCH, 2012, 18 (03)
12345