Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria

被引：12
|
作者：
Vasconcelos, Nathalie Gaebler [1 ,2 ]
Croda, Julio [3 ,4 ]
Silva, Kesia Esther [1 ]
Leal Motta, Maria Lorenza [1 ]
Maciel, Wirlaine Glauce [1 ]
Limiere, Leticia Cristina [2 ]
Simionatto, Simone [1 ]
机构：
[1] Fundacao Univ Fed Grande Dourados, Lab Pesquisa Ciencias Saude, Dourados, MS, Brazil
[2] Fundacao Univ Fed Grande Dourados, Hosp Univ Dourados, Dourados, MS, Brazil
[3] Fundacao Oswaldo Cruz, Campo Grande, MS, Brazil
[4] Univ Fed Mato Grosso do Sul, Campo Grande, MS, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2019年 / 52卷
关键词：
Oregano; Carbapenemase; Multidrug resistance; Antimicrobial activity; EXTRACT;
D O I：
10.1590/0037-8682-0502-2018
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Introduction: Plant products are sources for drug development against multidrug resistant bacteria. Methods: The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. Results: Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. Conclusion: OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
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页数：5
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