Relationship Between ACE2 and Other Components of the Renin-Angiotensin System

被引：16
|
作者：
Cohen, Jordana B. [1 ,2 ]
Hanff, Thomas C. [2 ,3 ]
Bress, Adam P. [4 ]
South, Andrew M. [5 ,6 ,7 ,8 ]
机构：
[1] Univ Penn, Dept Med, Perelman Sch Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA
[3] Univ Penn, Dept Med, Perelman Sch Med, Div Cardiol, Philadelphia, PA 19104 USA
[4] Univ Utah, Dept Populat Hlth Sci, Div Hlth Syst Innovat & Res, Salt Lake City, UT USA
[5] Wake Forest Sch Med, Dept Pediat, Sect Nephrol, Winston Salem, NC 27101 USA
[6] Brenner Childrens Hosp, Winston Salem, NC USA
[7] Wake Forest Sch Med, Div Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27101 USA
[8] Wake Forest Sch Med, Dept Surg Hypertens & Vasc Res, Winston Salem, NC 27101 USA
来源：
CURRENT HYPERTENSION REPORTS | 2020年 / 22卷 / 07期
关键词：
COVID-19; Angiotensin-converting enzyme; Renin-angiotensin system; Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; Hypertension; Coronavirus infections; Chronic kidney disease; Cardiovascular disease; CONVERTING ENZYME-2 ACE2; CLINICAL CHARACTERISTICS; INHIBITION; EXPRESSION; BLOCKADE; FIBROSIS; INJURY; AXIS;
D O I：
10.1007/s11906-020-01048-y
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Purpose of the Review Angiotensin-converting enzyme 2 (ACE2) is a key counter-regulatory component of the renin-angiotensin system. Here, we briefly review the mechanistic and target organ effects related to ACE2 activity, and the importance of ACE2 in SARS-CoV-2 infection. Recent Findings ACE2 converts angiotensin (Ang) II to Ang-(1-7), which directly opposes the vasoconstrictive, proinflammatory, and prothrombotic effects of Ang II. ACE2 also facilitates SARS-CoV-2 viral entry into host cells. Drugs that interact with the renin-angiotensin system may impact ACE2 expression and COVID-19 pathogenesis; however, the magnitude and direction of these effects are unknown at this time. High quality research is needed to improve our understanding of how agents that act on the renin-angiotensin system impact ACE2 and COVID-19-related disease outcomes.
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页数：5
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