Possible roles of epigenetics in stem cell therapy for Parkinson's disease

被引：5

作者：

Thompson, Cassandra ^{[1
,2
]}

Otero, Paulina ^{[1
,2
]}

Srinageshwar, Bhairavi ^{[1
,2
,3
]}

Petersen, Robert B. ^{[3
]}

Dunbar, Gary L. ^{[1
,2
,3
,4
,5
]}

Rossignol, Julien ^{[1
,2
,3
]}

机构：

[1] Cent Michigan Univ, Lab Restorat Neurol, Field Neurosci Inst, Mt Pleasant, MI 48859 USA

[2] Cent Michigan Univ, Program Neurosci, Mt Pleasant, MI 48859 USA

[3] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA

[4] Cent Michigan Univ, Dept Psychol, Mt Pleasant, MI 48859 USA

[5] St Marys Michigan, Field Neurosci Inst, Saginaw, MI 48604 USA

来源：

EPIGENOMICS | 2020年 / 12卷 / 07期

关键词：

epigenetics; methylation; Parkinson's disease; stem cells; stem cell therapy; stem cell transplantations; ALPHA-SYNUCLEIN EXPRESSION; DOPAMINERGIC-NEURONS; RAT MODEL; TRANSPLANTATION; BRAIN; DIFFERENTIATION; METHYLATION; MECHANISMS; SYMPTOMS; SURVIVAL;

D O I：

10.2217/epi-2019-0347

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Parkinson's disease (PD) is a neurodegenerative disease with loss of dopaminergic neurons. PD has genetic and epigenetic influences that determine specific changes in the brain. Epigenetic changes result in defective methylation of genes leading to differential gene-expression causing PD. This review provides an overview of stem cell transplantations as potential therapies for PD, with a focus on the epigenetic changes, prior or following transplantation. To date, no reports have addressed epigenetic alterations following stem cell transplantation into the PD brain. Given the potential for affecting the efficacy of stem cell therapy, increased attention needs to be given to the epigenetic processes that occur during stem cell culture and transplantation to maximize the therapeutic potential of stem cells to PD. Graphical abstract

引用

页码：647 / 656

页数：10

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