Antiparasitic Activity and Essential Oil Chemical Analysis of the Piper Tuberculatum Jacq Fruit

被引：0

作者：

Sales, Valterlucio dos Santos ^{[1
]}

Monteiro, Alefe Brito ^{[1
]}

Delmondes, Gyllyandeson de Araujo ^{[1
]}

do Nascimento, Emmily Peticia ^{[1
]}

Dantas Nobrega de Figueiredo, Francisco Rodolpho Sobreira ^{[1
]}

de Souza Rodrigues, Cristina Kelly ^{[1
]}

Evangelista de Lacerda, Josefa Fernanda ^{[1
]}

Fernandes, Cicera Norma ^{[1
]}

Barbosa, Maysa de Oliveira ^{[1
]}

Brasil, Adamo Xenofonte ^{[1
]}

Tintino, Saulo Relison ^{[1
]}

Vega Gomez, Maria Celeste ^{[2
]}

Coronel, Cathia ^{[2
]}

Melo Coutinho, Henrique Douglas ^{[1
]}

Martins da Costa, Jose Galberto ^{[1
]}

Bezerra Felipe, Cicero Francisco ^{[3
]}

Alencar de Menezes, Irwin Rose ^{[1
]}

Kerntopf, Marta Regina ^{[1
]}

机构：

[1] Reg Univ Cariri, Dept Biol Chem, Crato, CE, Brazil

[2] Fdn Moises Bertoni, Labs Diaz Gill, Ctr Dev Sci Res, Asuncion, Paraguay

[3] Univ Fed Paraiba, Dept Mol Biol, Joao Pessoa, Paraiba, Brazil

来源：

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2018年 / 17卷 / 01期

关键词：

Antiparasitic activity; Piper tuberculatum Jacq; Essential oil; Terpenes; Natural products; EXPRESSING BETA-GALACTOSIDASE; BENZOIC-ACID DERIVATIVES; RICH ESSENTIAL OIL; ANTILEISHMANIAL ACTIVITY; TRYPANOSOMA-CRUZI; IN-VITRO; MEDICINAL-PLANTS; COMPONENTS; AGENTS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

With the increase of neglected diseases such as leishmaniasis and Chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. Thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of Piper tuberculatum Jacq, against lines of Leishmania braziliensis (MHOM/CO/88/UA301), Leishmania infantum (MHOM/ES/92/BCN83) and Trypanosoma cruzi (LC-B5 clone). Before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes. As major constituents, beta-pinene and a-pinene were identified. Regarding to antiparasitic activity, the essential oil had an EC50 values of 133.97 mu g/mL and 143.59 mu g/mL against variations promastigotes of L. infantum and L. braziliensis, respectively. As for trypanocidal activity, the oil showed EC50 value of 140.31 mu g/mL against epimastigote form of T. cruzi. Moreover, it showed moderate cytotoxicity in fibroblasts with LC50 value of 204.71 mu g/mL. The observed effect may be related to the presence of terpenes contained in the essential oil, since it has its antiparasitic activity proven in the literature.

引用

页码：268 / 275

页数：8

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