Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases

被引:3
|
作者
Fischer, Jean, V [1 ]
Mejia-Bautista, Melissa [1 ]
Vadasz, Brian [1 ]
Yin, Ping [2 ]
Bulun, Serdar [2 ]
Tanner, Edward J. [2 ]
Lu, Xinyan [1 ]
Wei, Jian-Jun [1 ,2 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, 251 East Huron St,Feinberg 7-334, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
Leiomyoma with bizarre nuclei; Leiomyosarcoma; Histology; DNA Copy number alteration; Uterus; SMOOTH-MUSCLE TUMORS; ATYPICAL LEIOMYOMA; VARIANTS; EMPHASIS; UTERUS; PTEN;
D O I
10.1097/PGP.0000000000000837
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with overall benign clinical course. It has histologic features showing focal or diffuse nuclear atypia surrounded by usual type leiomyoma. Uterine leiomyosarcomas (LMS) are a group of rare and aggressive malignancies with limited treatment options available. The potential association between LM-BN with LMS is largely unknown. In this study, we report 2 cases of uterine smooth muscle tumor with typical histologic and molecular evidence of LM-BN, which are associated with its progression to the malignant counterpart of LMS. We summarize the detailed histologic, morphologic, and genomic characteristics of these 2 sets of cases. Our findings suggest that LMS progressing from preexisting LM-BN can be one of the tumor pathogenesis pathways in uterine leiomyosarcomas.
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页码:552 / 565
页数:14
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