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Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases
被引:3
|作者:
Fischer, Jean, V
[1
]
Mejia-Bautista, Melissa
[1
]
Vadasz, Brian
[1
]
Yin, Ping
[2
]
Bulun, Serdar
[2
]
Tanner, Edward J.
[2
]
Lu, Xinyan
[1
]
Wei, Jian-Jun
[1
,2
]
机构:
[1] Northwestern Univ, Feinberg Sch Med, Dept Pathol, 251 East Huron St,Feinberg 7-334, Chicago, IL 60611 USA
[2] Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA
基金:
美国国家卫生研究院;
关键词:
Leiomyoma with bizarre nuclei;
Leiomyosarcoma;
Histology;
DNA Copy number alteration;
Uterus;
SMOOTH-MUSCLE TUMORS;
ATYPICAL LEIOMYOMA;
VARIANTS;
EMPHASIS;
UTERUS;
PTEN;
D O I:
10.1097/PGP.0000000000000837
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with overall benign clinical course. It has histologic features showing focal or diffuse nuclear atypia surrounded by usual type leiomyoma. Uterine leiomyosarcomas (LMS) are a group of rare and aggressive malignancies with limited treatment options available. The potential association between LM-BN with LMS is largely unknown. In this study, we report 2 cases of uterine smooth muscle tumor with typical histologic and molecular evidence of LM-BN, which are associated with its progression to the malignant counterpart of LMS. We summarize the detailed histologic, morphologic, and genomic characteristics of these 2 sets of cases. Our findings suggest that LMS progressing from preexisting LM-BN can be one of the tumor pathogenesis pathways in uterine leiomyosarcomas.
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页码:552 / 565
页数:14
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