In vitro and in vivo antioxidant properties of Vaccinium myrtillus

被引：10
|
作者：
Martín-Aragón, S [1 ]
Basabe, B [1 ]
Benedí, JM [1 ]
Villar, AM [1 ]
机构：
[1] Univ Complutense Madrid, Fac Pharm, Dept Pharmacol, Madrid, Spain
来源：
PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 02期
关键词：
anthocyanoside; lipid peroxidation; liver; superoxide anion; Vaccinium myrtillus;
D O I：
10.1076/phbi.37.2.109.6091
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
In vitro and in vivo antioxidant properties of an anthocyanoside complex extract from Vaccinium myrtillus (AVM) were evaluated. This extract scavenged superoxide anion in the hypoxanthine-xanthine oxidase system and inhibited CCl4-NADPH-stimulated lipid peroxidation irt microsomes. It was found that pretreatment of mice with 250 and 500 mg/kg oral dosages, respectively: of AVM inhibited significantly liver lipid peroxidation stimulated by FeCl2-ascorbic acid-ADP mixture. These results suggest that AVM might be useful as a liver protective agent and in the prevention of other diseases caused by oxidative stress.
引用
收藏
页码：109 / 113
页数：5
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