Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

被引:73
|
作者
Yao, Qing [1 ,2 ]
Lan, Qing-Hua [2 ]
Jiang, Xinyu [3 ]
Du, Chu-Chu [2 ]
Zhai, Yuan-Yuan [2 ]
Shen, Xiaohan [4 ]
Xu, He-Lin [2 ]
Xiao, Jian [2 ]
Kou, Longfa [3 ]
Zhao, Ying-Zheng [1 ,2 ]
机构
[1] Wenzhou Med Univ, Dept Ultrasonog, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China
[3] Wenzhou Med Univ, Dept Pharm, Affiliated Hosp & Yuying Childrens Hosp 2, Wenzhou 325035, Peoples R China
[4] Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Oncol, Cixi 315300, Peoples R China
来源
THERANOSTICS | 2020年 / 10卷 / 25期
基金
中国国家自然科学基金;
关键词
biliverdin; silk fibroin; hydrogel; photothermal therapy; wound healing; ISCHEMIA-REPERFUSION INJURY; SILK FIBROIN; CANCER; DELIVERY; NANOPARTICLES; SCAFFOLD; REGENERATION; MACROPHAGES; BILIRUBIN; BIOMATERIALS;
D O I
10.7150/thno.47682
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under the near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR irradiation might damage the adjacent tissue due to the leakage of the photoabsorbers and the residual materials after treatment might hinder the local healing process. A bifunctional hydrogel that holds both photothermal property and potent pro-healing ability provides a viable option to resolve this issue. Methods: In this study, we developed a bioinspired green hydrogel (BVSF) with the integration of bioproduct biliverdin into natural derived silk fibroin matrix for antiglioma photothermal therapy and wound healing. Results: The BVSF hydrogel possessed excellent and controllable photothermal activity under NIR irradiation and resulted in effective tumor ablation both in vitro and in vivo. Additionally, the BVSF hydrogel exerted anti-inflammatory effects both in vitro and in vivo, and stimulated angiogenesis and wound healing in a full-thickness defect rat model. Conclusion: Overall, this proof-of-concept study was aimed to determine the feasibility and reliability of using an all-natural green formulation for photothermal therapy and post-treatment care.
引用
收藏
页码:11719 / 11736
页数:18
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