Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus

被引：17

作者：

Casu, L

Bonsignore, L

Pinna, M

Casu, M

Floris, C

Gertsch, J

Cottiglia, F

机构：

[1] Univ Cagliari, Dipartimento Farmaco Chim Tecnol, I-09124 Cagliari, Italy

[2] Univ Cagliari, Dipartimento Sci Chim, I-09042 Monserrato, Italy

[3] Swiss Fed Inst Technol, Inst Pharmaceut Sci, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 02期

关键词：

D O I：

10.1021/np0504513

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural,class, were isolated from the leaves of Plagius,flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC50 values ranging frorn 4 to 6 mu M.

引用

页码：295 / 298

页数：4

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