A novel method for the conversion of carboxylic acids to N,N-dimethylamides using N,N-dimethylacetamide as a dimethylamine source

被引：4

作者：

Aavula, Sanjeev Kumar ^{[1
]}

Chikkulapally, Anil ^{[1
]}

Hanumanthappa, N. ^{[1
]}

Jyothi, Indira ^{[1
]}

Kumar, C. H. Vinod ^{[1
]}

Manjunatha, Sulur G. ^{[1
]}

Sythana, Suresh Kumar ^{[1
]}

机构：

[1] AstraZeneca India Pvt Ltd, Pharmaceut Dev, Bangalore 560024, Karnataka, India

来源：

JOURNAL OF CHEMICAL RESEARCH | 2013年 / 03期

关键词：

N; N-dimethylacetamide; 1,1 '-carbonyldiimidazole; carboxylic acids; amidation; one-pot synthesis;

D O I：

10.3184/174751913X13602686612047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, cost effective and environmentally benign method is reported for the preparation of N,N-dimethylamides from carboxylic acids. The versatility of the method is determined by synthesising a large number of N,N-dimethylamide derivatives. Carboxylic acids are heated at 160-165 degrees C in N,N-dimethylacetamide solvent in the presence of 1,1'-carbonyldiimidazole to afford the corresponding N, N-dimethylamides in good to excellent yields.

引用

页码：155 / 159

页数：5

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