Novel roles for TIM-1 in immunity and infection

被引:63
|
作者
Rennert, Paul D. [1 ]
机构
[1] Biogen Idec Inc, Dept Mol Discovery & Immunobiol, Cambridge, MA 02142 USA
关键词
T cells; Dendritic cells; Phosphatidylserine; Asthma; Hepatitis A virus; Filovirus; HEPATITIS-A VIRUS; T-CELL IMMUNOGLOBULIN; PHOSPHATIDYLSERINE RECEPTOR; MUCIN DOMAIN; AIRWAY HYPERREACTIVITY; GENE FAMILY; IG DOMAIN; NKT CELLS; BINDING; TOLERANCE;
D O I
10.1016/j.imlet.2011.08.003
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell, immunoglobulin domain and mucin domain-1 (TIM-1) is the nominant member of a small family of related proteins that regulate immune cell activities. TIM-1 was initially characterized in a mouse congenic analysis of Th2 T cell responses and related pathology. Data accumulated to date suggest that TIM-1 regulates effector T cell function, and may play distinct roles in the activities of B cells, invariant NKT cells and epithelial cells. In addition, a variety of ligands for TIM-1 have been proposed. In this review I discuss recent data that have accumulated on the function of TIM-1, propose a model to explain how TIM-1 regulates effector T cell activity through recognition of distinct ligands, and review others functions of this increasingly fascinating protein. Of considerable interest are the novel findings that TIM-1 mediates virus entry and virulence. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:28 / 35
页数:8
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