Discordance of apolipoprotein B with low-density lipoprotein cholesterol or non-high-density lipoprotein cholesterol and coronary atherosclerosis

被引:16
|
作者
Su, Xin [1 ,2 ]
Cai, Xueli [3 ]
Pan, Yuesong [4 ,5 ]
Sun, Jingping [3 ]
Jing, Jing [4 ,5 ]
Wang, Mengxing [4 ,5 ]
Meng, Xia [4 ,5 ]
Wang, Yongjun [4 ,5 ]
Wei, Tiemin [6 ]
He, Yan [1 ,2 ]
机构
[1] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing, Peoples R China
[2] Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China
[3] Zhejiang Univ, Lishui Hosp, Dept Neurol, Sch Med, Lishui, Peoples R China
[4] Capital Med Univ, Dept Neurol, Beijing Tiantan Hosp, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
[6] Zhejiang Univ, Lishui Hosp, Dept Cardiol, Sch Med, Lishui, Peoples R China
基金
中国国家自然科学基金;
关键词
Apolipoproteins; Coronary atherosclerosis plaques; Discordance analysis; Lipoproteins; PROGNOSTIC VALUE; LDL-CHOLESTEROL; ARTERY CALCIFICATION; COMPUTED-TOMOGRAPHY; RISK; ANGIOGRAPHY; DISEASE; EVENTS; DYSLIPIDEMIA; MANAGEMENT;
D O I
10.1093/eurjpc/zwac223
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims High level of apolipoprotein B (Apo B) is associated with incident subclinical atherosclerosis. The present study evaluated the associations between discordant Apo B with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and coronary atherosclerotic burden. Methods and results This study enrolled 3043 participants aged 50-75 years from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study that was conducted in the community in Lishui City, China. Discordant Apo B with LDL-C and non-HDL-C were defined by residuals and medians. Coronary atherosclerotic burden was evaluated by segment involvement score (SIS) and segment stenosis score (SSS) which were determined by computed tomography angiography. We performed discordance analyses examining associations of discordant Apo B with LDL-C or non-HDL-C with the coronary atherosclerotic burden. The mean age of participants was 61.2 +/- 6.7 years, 53.6% were females. Participants with discordant high Apo B relative to non-HDL-C were at higher odds of plaques [odds ratio (OR), 1.30; 95% confidence interval (CI), 1.08-1.57], SIS [common odds ratio (cOR), 1.35; 95% CI, 1.14-1.60], and SSS (cOR, 1.40; 95% CI, 1.18-1.67) compared with concordant group. However, discordantly low Apo B with non-HDL-C was associated with decreased odds of the coronary atherosclerotic plaques and its burden. Similar results were shown for discordant analyses for Apo B with LDL-C. Conclusion Discordantly high Apo B with LDL-C and non-HDL-C were associated with an increased odds of the coronary atherosclerotic plaques and its burden. These findings highlighted the importance of Apo B for primary prevention of coronary atherosclerosis.
引用
收藏
页码:2349 / 2358
页数:10
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