Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats

被引：52
|
作者：
Sun, J. [1 ]
Yang, D. [1 ]
Li, S. [1 ]
Xu, Z. [2 ]
Wang, X. [1 ]
Bai, C. [1 ]
机构：
[1] Fudan Univ, Dept Pulm Med, Zhongshan Hosp, Shanghai 200032, Peoples R China
[2] Fudan Univ, Dept Pathol, Shanghai 200032, Peoples R China
来源：
EUROPEAN RESPIRATORY JOURNAL | 2009年 / 33卷 / 02期
关键词：
Curcumin; ischaemia-reperfusion; lung; microvascular permeability; nuclear factor-kappa B; oxidative stress; FACTOR-KAPPA-B; TRANSPLANTATION; CELLS; ACTIVATION; EXPRESSION; ISCHAEMIA/REPERFUSION; PRESERVATION; INFLAMMATION; STRESS;
D O I：
10.1183/09031936.00142407
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
The present study aimed to investigate potential effects of curcumin (CUR) and dexamethasone I on ischaemia-reperfusion (I/R) induced lung injury in rats. Experimental rats were pre-treated with a single i.p. dose of vehicle, CUR (50 mg.kg(-1) or 200 mg.kg(-1)) or DXM (5 mg.kg(-1)), 2 h before anaesthesia and subjected to left lung hilus clamping with 90-min ischaemia followed by 4 h of reperfusion. Pre-treatment with CUR (200 mg.kg(-1) or DXM markedly attenuated I/R-induced barrier disruption, lung oedema, tissue inflammation, hypoxaemia 4 h after reperfusion, and over-activation of nuclear factor-kappa B inflammatory cytokines, myeloperoxidase and malondialdehyde. It appears that curcumin attenuates acute lung injury, probably through improving oxidative stress and inhibiting nuclear factor-kappa B-mediated expression of inflammatory cytokines. Thus, curcumin may be an alternative therapy for improving the outcomes of ischaemia-reperfusion-induced lung injury.
引用
收藏
页码：398 / 404
页数：7
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