Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

被引：31
|
作者：
Ashmus, Roger A. [1 ]
Schocker, Nathaniel S. [1 ]
Cordero-Mendoza, Yanira [2 ]
Marques, Alexandre F. [2 ]
Monroy, Erika Y. [1 ]
Pardo, Andrew [1 ]
Izquierdo, Luis [3 ]
Gallego, Montserrat [3 ]
Gascon, Joaquim [3 ]
Almeida, Igor C. [2 ]
Michael, Katja [1 ]
机构：
[1] Univ Texas El Paso, Dept Chem, El Paso, TX 79968 USA
[2] Univ Texas El Paso, Dept Biol Sci, Border Biomed Res Ctr, El Paso, TX 79968 USA
[3] Univ Barcelona, Hosp Clin, CRESIB, Barcelona Ctr Int Hlth Res, E-08036 Barcelona, Spain
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 34期
关键词：
ANTIBODIES; INFECTION; OLIGOSACCHARIDES; TRYPOMASTIGOTES; SERODIAGNOSIS; GLYCOPROTEINS; BENZNIDAZOLE; DERIVATIVES; EFFICACY; MUCINS;
D O I：
10.1039/c3ob40887f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A synthetic glycoarray containing non-reducing alpha-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Gal alpha(1,3)Gal beta as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.
引用
收藏
页码：5579 / 5583
页数：5
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